Stability of Ethyl Glucuronide, Ethyl Sulfate, Phosphatidylethanols and Fatty Acid Ethyl Esters in Postmortem Human Blood
نویسندگان
چکیده
منابع مشابه
Red blood cell fatty acid ethyl esters: a significant component of fatty acid ethyl esters in the blood.
Although alcohol abuse is known to cause an array of ethanol-induced red blood cell (RBC) abnormalities, the underlying molecular mechanisms remain poorly understood. Fatty acid ethyl esters (FAEEs) are toxic, nonoxidative ethanol metabolites that have been found in blood, plasma, and tissues. Because FAEEs have been shown to be incorporated into phospholipid bilayers, we conducted a controlled...
متن کاملIn vitro formation of ethyl glucuronide and ethyl sulfate
Aims: Ethyl glucuronide (EtG) and ethyl sulfate (EtS) are used as markers of alcohol consumption in various clinical and forensic settings. In controlled studies, their concentration considerably varies between subjects. Knowledge on glucuronosyltransferases (UGT) and sulfotransferases (SULT) catalyzing formation of EtG and EtS formation is as moderate as diverging. A possible influence of nutr...
متن کاملWorkplace alcohol testing program by combined use of ethyl glucuronide and fatty acid ethyl esters in hair.
AIMS The applicability of fatty acid ethyl esters (FAEEs) and ethyl glucuronide (EtG) in hair in a workplace alcohol testing program was investigated. METHODS A total of 78 hair samples from employees in jobs with a high endangering potential were tested for EtG and FAEEs. In most cases excessive drinking was suspected. For 59 of these cases additional data of the traditional alcohol markers ...
متن کاملClinical sensitivity and specificity of meconium fatty acid ethyl ester, ethyl glucuronide, and ethyl sulfate for detecting maternal drinking during pregnancy.
BACKGROUND We investigated agreement between self-reported prenatal alcohol exposure (PAE) and objective meconium alcohol markers to determine the optimal meconium marker and threshold for identifying PAE. METHODS Meconium fatty acid ethyl esters (FAEE), ethyl glucuronide (EtG), and ethyl sulfate (EtS) were quantified by LC-MS/MS in 0.1 g meconium from infants of Safe Passage Study participan...
متن کاملValue of Ethyl Glucuronide and Ethyl Sulfate in Serum as Biomarkers of Alcohol Consumption
BACKGROUND Urinary Ethyl glucuronide (EtG) and Ethyl sulfate (EtS) are established markers of alcohol conumption. Measurement of these markers in serum offers certain advantages. This outpatient department based study evaluated performance of serum Ethyl glucuronide (EtG) and Ethyl sulphate (EtS) as biomarkers of recent alcohol consumption in alcohol dependent subjects. It also evaluated effect...
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ژورنال
عنوان ژورنال: Journal of Analytical Toxicology
سال: 2018
ISSN: 0146-4760,1945-2403
DOI: 10.1093/jat/bky010